Magnesium and Its Role in Primary Open Angle Glaucoma; A Novel Therapeutic?

Glaucoma is the leading cause of irreversible blindness globally, with Primary open angle glaucoma (POAG) being commonest subtype. POAG characterized by an increase in intraocular pressure (IOP), to optic nerve damage and subsequent visual field defects. Despite clinical burden this disease poses, current therapies aim reduce IOP rather than targeting underling pathogenesis. Although pathogenesis complex, culprit for resides aqueous humour (AH) outflow pathway; trabecular meshwork (TM) Schlemm’s canal. Dysfunction these tissues due inherent mitochondrial dysfunction, calcium influx sensitivity, reactive oxygen species (ROS) production, TGFβ-2 induction, a sustained inflammatory response. Magnesium second most common intracellular cation, major co-factor over 300 reactions, highly conserved within energy-dependent organelles such as mitochondria. deficiency has been observed linked fibrotic responses, well increased oxidative stress (OS). supplementation shown cellular ROS, alleviate dysregulation further antifibrotic anti-inflammatory properties ocular tissues, other soft prone fibrosis, suggesting that magnesium can improve fields patients POAG. The link between potential role management will be explored review.